【摘要】据估计，10-20%的青少年存在心理健康问题，其中大多数仍未得到充分诊断和治疗。因此，发现新的易感性生物标志物对于识别出现心理健康问题的高风险个体并改善早期预防非常重要。在这里，我们的目标是在11-16岁有心理健康问题风险的儿童/青少年中发现基于血浆蛋白的易感性生物标志物。根据自我报告的优势和困难问卷（SDQ）评分评估风险，并通过液相色谱-串联质谱法获得参与西班牙WALNUTs队列研究的个体的血浆蛋白质组数据。进行生物信息学分析，以确定所确定的候选生物标志物所涉及的生物过程和途径。发现58个蛋白质与SDQ评分显着相关。与这些蛋白质相关的最显著的富集途径包括免疫反应、凝血、神经发生和神经元变性。这项探索性研究揭示了青少年中与SDQ评分相关的血浆蛋白的一些变化，这开辟了开发新型易感性生物标志物的新途径，以改善对有心理健康问题风险的个体的早期识别。

[Abstract] An estimated 10–20% of adolescents experience mental health conditions, and most of them remain underdiagnosed and undertreated. Discovering new susceptibility biomarkers is therefore important for identifying individuals at high risk of developing mental health problems, and for improving early prevention. Here we aimed to discover plasma protein-based susceptibility biomarkers in children/adolescents aged 11–16 years at risk of developing mental health issues. Risk was evaluated on the basis of self-reported Strengths and Difficulties Questionnaire (SDQ) scores, and plasma proteomic data were obtained for individuals participating in the Spanish WALNUTs cohort study by liquid chromatography–tandem mass spectrometry. Bioinformatic analyses were performed to identify the biological processes and pathways in which the identified biomarker candidates are involved; 58 proteins were significantly associated with the SDQ score. The most prominent enriched pathways related to these proteins included immune responses, blood coagulation, neurogenesis and neuronal degeneration. This exploratory study revealed several alterations of plasma proteins associated with the SDQ score in adolescents, which opens a new avenue to develop novel susceptibility biomarkers to improve early identification of individuals at risk of mental health problems.

论文原文：Izaque de Sousa Maciel, Aino-Kaisa Piironen, Alexey M. Afonin, Mariia Ivanova, Arto Alatalo, Kaustubh Kishor Jadhav, Jordi Julvez, Maria Foraster, Irene van Kamp & Katja M. Kanninen (2023). Plasma proteomics discovery of mental health risk biomarkers in adolescents. Nature - Mental Health, 1 (8): 596–605.

https://doi.org/10.1038/s44220-023-00103-2

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