慢性阻塞性肺病的性健康：系统评价和荟萃分析

Sexual Health in COPD: A Systematic Review and Meta-Analysis

——原载《国际慢性阻塞性肺病杂志》2022年第17卷——

<International Journal of Sexual Health>, 2022, 17

【摘要】慢性阻塞性肺病（COPD）对患者及其伴侣的生活产生深远影响，但对性健康的生理、心理和社会方面的影响尚未得到系统评价。两位作者在 PubMed、PsycINFO、Embases、CINAHL、Web of Science、Scopus 和 Cochrane 图书馆的数据库中独立进行了关于COPD对性健康影响的研究的搜索。对诊断为慢性阻塞性肺病的患者评估性健康的一个或多个方面的英语定量和定性研究进行了叙述性审查，并在可能的情况下进行荟萃分析评估。共纳入31项研究，包括4项定性研究。对使用国际勃起功能指数评估勃起功能障碍的12项研究进行了荟萃分析。在总共1187名COPD患者中，勃起功能障碍的合并患病率为74%（95% CI：68-80%），而在224名年龄匹配的非COPD对照中，勃起功能障碍的患病率为56%（37-73%）。其余研究中评估的性健康结果差异很大，影响了结果的可比性。没有一项定性研究将性健康作为主要关注点。与非慢性阻塞性肺病患者相比，勃起功能障碍似乎在慢性阻塞性肺病患者中更为普遍，但需要更多包括非慢性阻塞性肺病对照的研究来证实这一发现。此外，由于缺乏可比较的评估方法和研究设计，COPD对性健康的其他生理、心理和社会方面的影响仍不清楚。

【关键词】性问题，慢性阻塞性肺病，社会心理方面，性别，生活质量，系统评价

[Abstract] COPD has a profound impact on the lives of patients and their partners, but the influence on physical, psychological and social aspects of sexual health has not been reviewed systematically. Searches for studies of the impact of COPD on sexual health were conducted independently by two authors in the databases of PubMed, PsycINFO, Embases, CINAHL, Web of Science, Scopus and The Cochrane Library. English-language quantitative and qualitative studies assessing one or more aspects of sexual health in patients diagnosed with COPD were narratively reviewed and, when possible, subjected to meta-analytic evaluation. A total of 31 studies, including 4 qualitative, were included. Twelve studies assessing erectile dysfunction with the International Index of Erectile Function were subjected to meta-analysis. The pooled prevalence of erectile dysfunction was 74% (95% CI: 68–80%) in a total of 1187 patients with COPD, compared with 56%(37–73%) in 224 age-matched, non-COPD controls. The sexual health outcomes assessed in the remaining studies varied considerably, compromising the comparability of the results. None of the qualitative studies had sexual health as their primary focus. Compared with non-COPD individuals, erectile dysfunction appears to be more prevalent among patients with COPD, but more studies including non-COPD controls are needed to confirm this finding. In addition, the impact of COPD on other physical, psychological and social aspects of sexual health remains unclear due to the lack of comparable assessment methods and study designs.

[Key words] sexual problems, chronic obstructive pulmonary disease, psychosocial aspects, gender, quality of life, systematic review

论文原文：IngeborgFarver-Vestergaard, Yoon Frederiksen, Robert Zachariae,  Sandra Rubio-Rask and Anders Løkke (2022). Sexual Health in COPD: A Systematic Review and Meta-Analysis. International Journal of Chronic Obstructive Pulmonary Disease, 2022, 17: 297-315.

doi:  10.2147/COPD.S347578

（需要论文英文原文的朋友，请联系微信：millerdeng95）